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Acid Reflux Causing Mouth Sores 05.09.2012 · There are so many causes for canker sores that range from crohns to SlS in toothpaste to a vitamin deficiancy. I also take a prescription mouth rinse, Chlorhexidine Gluconate oral rinse,that could be helping me too. Acid Backup Those with acid reflux problems may also be more prone to dry mouth. This is because